Description:
Maple Syrup Urine Disease (MSUD), also called branched-chain ketoaciduria, is an autosomal recessive metabolic disorder affecting branched-chain amino acids (BCAAs). Screening is conducted in the Philippines to detect MSU in newborns. This article discusses experimental research utilizing bacterial inhibition assay, specifically Escherichia coli MCC-MNH 1958, to detect excess BCAAs.
Learning Objectives:
- Describe bacterial inhibition assay and the procedure
- Explain the uses of the bacterial inhibition assay
- Discuss the potential of Escherichia coli to detect Maple Syrup Urine Disease
Author(s):
Jon Paul M. Reyes, PhD, RMT, AHI (AMT), MSMLS, MBA, CHRA, DPed
Oliver Shane R. Dumaoal, RMT, MSMT, CBO, IFBA PC
Launched: 2023