STEP 473: The Effect of Various Fatty Acids on Activity of G6Pase-Α and PDK4 in HEPG2 Cells (CE: 1.0)


It has been reported that 23% of adults in the U.S. have metabolic syndrome. Although this is generally a combined risk of the high blood pressure along with high serum glucose and cholesterol levels, metabolic syndrome is best explained by insulin resistance with evidence indicating that it begins with excess central adiposity. This article covers the benefits of fatty acids on the activities of G6Pase-α and PDK4, both in the presence and absence of insulin.


Learning Objectives:

  • Outline beneficial fatty acids
  • Describe genetic mechanisms involved in the insulin pathway
  • Discuss the effects of fatty acids in the presence and absence of insulin



Lisa Maness, MT (ASCP, AMT), PhD


Launched: 2020