Shifts in patient results due to reagent lot changes
(lot-to-lot variation, L2L) are a major issue for laboratories, and their
investigation is both time-consuming and expensive. The effect that reagent
lot-to-lot changes can have on patient results and how these shifts, if large
enough, could lead to misdiagnosis and inappropriate treatment. This article
discusses a way to detect those analytes that in the past, have been seen to
vary from lot to lot and proposes a way to measure changes due to L2L variation.
Discuss how to measure changes due to L2L variations